After Peyton Place was published in 1956, it sold extremely well. The film rights were sold within a month of the novel being released; Grace Metalious was hired as a story consultant, but she quickly became unhappy with the way her novel was being adapted. Part of the novel’s appeal stemmed from its relatively frank depiction of sexuality, as well as taboo topics including incest and abortion. However, in the 1950s, the American film industry was governed by the Hays Code (which remained in effect until 1968). These guidelines restricted Hollywood films from depicting or alluding to many subjects, particularly topics relating to sexuality. The film adaptation (also titled Peyton Place) was released in December 1957; it starred Lana Turner as Constance MacKenzie. While many aspects of the plot were retained, significant changes were made. Notably, both plotlines surrounding abortion were removed from the film adaptation: while Selena Cross does get pregnant due to being sexually abused by her stepfather, she suffers an accidental miscarriage (which Dr. Swain helps her to conceal). In the film version, Rodney and Betty elope after his father objects to their relationship.

The film adaptation of Peyton Place was the second highest grossing film in the United States in 1957, building on the success of the novel.